Challenges

Challenges are unique runs in the game. Isaac typically starts each challenge with one or more specific items which makes normal play more difficult. With few exceptions, Treasure Rooms are not available during challenges. Each challenge unlocks new content for the game, such as runes when completed. You can find more information on the Binding of Isaac Rebirth Wiki.

Notes

• The challenge reward will not be unlocked unless the trophy is picked up. If a Devil Room or Angel Room appears allowing Isaac to go to Sheol or the Cathedral, the unlock will be forfeited.
• Isaac will not start any challenge with The D6.

Challenges List

Name	Conditions	Goal	Unlocked by	Unlocks
Did I Hear ‘Boom?’			Default	TBA
Go Fetch!			Default	Small Dog
Unnamed Fetus			Default	TBA