Challenges

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Challenges are unique runs in the game. Isaac typically starts each challenge with one or more specific items which makes normal play more difficult. With few exceptions, Treasure Rooms are not available during challenges. Each challenge unlocks new content for the game, such as runes when completed. You can find more information on the Binding of Isaac Rebirth Wiki.

Notes

  • The challenge reward will not be unlocked unless the trophy is picked up. If a Devil Room or Angel Room appears allowing Isaac to go to Sheol or the Cathedral, the unlock will be forfeited. (is this true for mods?)
  • Isaac will not start any challenge with The D6.

Challenges List

Name Conditions Goal Unlocked by Unlocks
Did I Hear ‘Boom?’ Isaac
Red HeartRed HeartRed Heart
Unknown Item Room : unknown
Shop: unknown
Unknown Default Script error: No such module "cargo".
Go Fetch! Isaac
Red HeartRed HeartRed Heart
Unknown Item Room : unknown
Shop: unknown
Unknown Default Dog Tag
Unnamed Fetus Isaac
Red HeartRed HeartRed Heart
Starts with:
Fat Fetus Fat Fetus
Item Room : no
Shop: yes
Mom Default Script error: No such module "cargo".